糖尿病视网膜病变患者血管内皮生长因子的测定及意义

Detecting and significance of vascular endothelial growth factor in patients with diabetic retinopathy

目的探讨血管内皮生长因子与非胰岛素依赖型糖尿病患者视网膜病变之间的关系。方法采用酶联免疫吸附测定法检测了52例非胰岛素依赖型糖尿病患者,其中31例伴DR,21例不伴视网膜病变和36例正常对照者血管内皮生长因子含量。结果各组糖尿病患者血管内皮生长因子值显著高于正常对照组(P<0.01),糖尿病无视网膜病变组、背景型及增殖型之间的血管内皮生长因子水平亦显著不同。结论血管内皮生长因子水平与糖尿病视网膜病变的病变程度密切相关。定期测定糖尿病人血中血管内皮生长因子可作为了解糖尿病视网膜病变程度的参考指标。

Objective To study the relationship between vascular endothelial growth factor （VEGF）in the patho- genesis of type 2 diabetes mellitus with retinopathy. Methods VEGF level was measured by enzyme linkedimmunosor- bent assay （ELISA） in of 36 control subjects and 52 patients with type 2 diabetes mellitus consisting of 31 eases of with diabetic retinopathy（DR） as well as 21 eases without retinopathy（NDR）. Results There were significantly differences in VEGF level between those of the normal control and retinopathy groups（ P 〈 0.01 ）. Level of VEGF was significantly differences among groups of NDR, BDR and PDR. Conclusions There is a positive correlation between DR and serum VEGF level in patients with diabetes mellitus, regularmonitor of serum VEGF level can be used as an important index of diabetic retinopathy.