摘要
目的：比较青蒿琥酯和巴利捷克治疗塞内加尔脑型疟病儿的疗效。方法：青蒿琥酯组１２０例（男７６例，女４４例；年龄６．９±３．１岁），剂量每次１．５ｍｇ／ｋｇ，ｉｖ或ｉｍ，于入院后即刻，ｈ４、ｈ２４、ｈ４８和ｈ７２给药；巴利捷克组１２０例（男７３例，女４７例；年龄６．８±３．０岁），剂量２５ｍｇ奎宁基质／（ｋｇ·ｄ），ｉｖ或ｉｍ，ｂｉｄ，３ｄ为一个疗程。结果：青蒿琥酯组较巴利捷克组治愈率高（Ｐ＜０．０１），治愈病儿昏迷清醒时间、退热时间、血疟原虫转阴时间和住院时间皆短（Ｐ均＜０．０１）。结论：青蒿琥酯治疗脑型疟病儿疗效优于巴利捷克。
Objective:To compare artesunate vs paluject on treating cerebral malaria in senegal.Methods:A hundred and twenty children (M76,F44;age 6.9±s3.1a) were given artesunate 1.5mg/kg,iv or im,immediately on admission,at h4,h24,h48 and h72.A hundred and twenty children (M73,F47;age 6.8±s3.0a),were given Paluject 25mg quining base/(kg/d),iv or im ,bid for 3d.Results:Total healing rates in the 2 groups were 88.3% and 73.3%,respectively (P<0.01).Artesunate group required less days for reviviscence,defervescence and clearing parasitemia,and less days of hospitalization,respectively (P<0.01),in comparison with paluject group.Conclusion:Artesunate is better than Paluject in treating children with cerebral malaria.
出处
《河北医学》
CAS
1998年第8期10-11,共2页
Hebei Medicine
