摘要
目的评价18F-FDG PET/CT显像在探测宫颈癌术后复发病灶中的应用价值。方法采用仪器为Siemens Biograph Sensation 16 PET/CT。56例病理证实宫颈癌患者,禁食4~6h,静脉注射18F-FDG 60min后进行PET/CT检查,采集方式为3D模式。由放射学与核医学各一位医生对其图像进行判定,与同期CT、SCC比较,并与手术病理或临床随访结果比较判断其诊断的准确性。结果经过病理和随访观察56例患者中有33例发生复发或(和)转移,18F-FDG PET/CT对复发性宫颈癌的灵敏度、特异性、阳性预测值、阴性预测值和准确性分别为93.1%(27/29)、88.9%(24/27)、90.0%(27/30)、92.3%(24/26)和91.1%(51/56)、CT分别为69.7%(23/33)、82.6%(19/23)、85.2%(23/27)、65.5%(19/29)和75.5%(42/56);SCC诊断效能分别为80.6%(25/31)、92.0%(23/25)、92.6%(25/27)、79.3%(23/29)和85.7%(48/56)。结论PET/CT显像对宫颈癌复发的检测具有较大的临床应用价值,特别是术后患者SCC升高的情况下,18F-FDG PET/CT有助于探测隐匿性复发或转移病灶,指导进一步的治疗。
Objective The value of integrated positron emission tomography （PET） and computed tomography （CT） for depiction of recurrent eervial cancer. Methods The model of PET/CT scanner we used is Siemens Biograph Sensation 16. Fifty-six women who had previously undergone surgery for ovarian cancer were included. The patients received ^18F-FDG intravenously after fasting for 4 to 6 hours. 3D whole body PET/CT scans were acquired 60 min after injection. PET/ CT imaging results were compared with the results of serum SCC levels and CT conventional imaging. PET/CT results were compared to histologic examination after surgery and clinical follow-up to determine the diagnostic accuracy of PET/CT in the evaluation of disease status. Results Of the 56 patients,33（58.9%） had recurrent disease,confirmed or endorsed by post-operation pathology,and（or）clinical follow-up.The sensitivity,specifieity,psitive predictive value（PPV）,negative predictive value（NPV）,and accuracy of ^18F-FDG PET/CT were 93.1%（27/29）,88.9%（24/27）,90.0%（27/30）,92.3%（24/26） and 91.1%（51/56）,those of CT were 69.7%（23/33）,82.6%（19/23）,85 .2%（23/27）,65.5%（19/29） and 75.0%（42/56） ,and those of SCC were 80.6%（25/31）,92.0%（23/25）,92.6%（25/27）,79.3%（23/2 9） and 85.7%（48/56） respetively.Conclusion ^18F-FDG PET/ CT has the highest clinical among ^18F-FDG PET/CT,CT,and SCC in detecting recurrent cervial cancer, especially in patients with increased SCC levels. ^18F-FDG PET/CT image can help to detect occult metastasis and direct further treatment to the precise site of tumor recurrence.
出处
《中国医疗设备》
2009年第8期20-22,共3页
China Medical Devices
