甘草次酸钠对环磷酰胺诱导的小鼠骨髓细胞姐妹染色单体互换及微核率的影响

Effects of Na-glycyrrhetinate on the Frequencise of Sister Chromatid Exchange(SCE)and Micronucleus in Mouse Bone Marrow Cells

本文观察了甘草次酸钠 GCN_a本身及其对环磷酰胺(CP)诱导的小鼠骨髓细胞姐妹染色单体互换(SCE)与微核率的影响。GCN_a 设10mg/kg 和20mg/kg 两个剂量组,分别腹腔注射,每天一次,共注射五次。与 CP 合用组在第五次给药同时腹腔注射 CP一次。结果 GCN_a 不影响 SCE 和微核率,说明GCN_a 没有致突作用;GCN_a 既不促进也不抑制 CP 诱导的 SCE 和微率,说明 GCN_a 对 CP 的致突作用无影响。

Sodium glycyrrhetinate GCN_a and its combination with cyclophosphamide (CP) to observe the effects of the frequencies of SCE and micronucleus of polychromatic erythrocyte in mouse bone marrow celle were stu- died.The dosages of GCN_a were arranged in two levels:10mg/kg and 20 mg/kg.The drug was adminis- tered ip,once a day for five days.20mg/kg CP was given ip only at the fifth day.The results were as follows: GCN_a could not affect the frequencies of SCE and micronucleus,indicating that the drug could not affect the action of mutagenesis.GCN_a neither Promoted nor prohibited the frequencies of SCE and micronucleus in- duced by CP,indicating that GCN_a could not affect the action of mutagenesis induced by CP also.