2-(E)-(3-甲氧基-4-羟基苯亚甲基)-5-(N-取代胺甲基)环戊酮的合成及抗炎活性研究

SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF 2-(E)-(4-HYDROXY-3-METHOXYBENZYLIDENE)-5-(N-SUBSTITUTED-AMINOMETHYL)- CYCLOPENTANONES

２（Ｅ）（３甲氧基４羟基苯亚甲基）５（Ｎ取代胺甲基）环戊酮的合成及抗炎活性研究董金华徐莉英秦华李莉许丁元计志忠（沈阳药科大学，沈阳１１００１５）目标化合物设计α亚甲基γ丁内酯和α亚甲基环酮有多种生理活性［１～３］，研究表明它...

In search for new antiinflammatory agents, a series of 2-(E)-(4-hydroxy-3-methoxybenzylidene)-5-(N-substituted aminomethyl) -cyclopentanones was synthesized via Stork reaction, Mannich reaction and amine exchange reaction. All of the fifteen target compounds were characterized by spectral analysis and elemental analysis. Preliminary pharmacological tests showed that several target compounds exerted appreciable effect on xyleneinduced ear edema in mice and that alteration of the substituents of anilines showed significant influence on antiinflammatory potency.