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辛伐他汀和胰岛素样生长因子-Ⅰ对人肺成纤维细胞增殖的影响 被引量:1

The Influences of insulin-like growth factor-Ⅰ and Simvastatin on the proliferation of human lung fibroblast
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摘要 目的研究辛伐他汀和胰岛素样生长因子-Ⅰ(IGF-Ⅰ)共同对人肺成纤维细胞(HFL-1)增殖的影响。方法培养人肺成纤维细胞,采用MTT法检测在辛伐他汀和IGF-Ⅰ单独/共同作用下对人肺成纤维细胞增殖的影响。结果辛伐他汀和IGF-Ⅰ共同作用于人肺成纤维细胞时,IGF-Ⅰ的促细胞增殖作用受到抑制。结论辛伐他汀可抑制IGF-Ⅰ对人肺成纤维细胞的促增殖作用。 Objective Study on the influences of Simvastatin and IGF-1 on the proliferation of human lung fibroblast.Methods human lung fibroblast was cultured and MTF colorimetry assay was used to determine the proliferation of human lung ftbroblast, the influences of IGF-1 and Simvastatin on the proliferation of human lung fibroblast was observed in vitro.Results The proliferation of human lung fibroblast was inhibited by Simvastatin. Combination of IGF -1 and Simvastatin can inhibit the proliferative capability of human lung fibroblast. Conclusion Simvastatin potently inhibited while IGF-Ⅰ stimulate human lung fibroblast proliferation.
出处 《中国实验诊断学》 北大核心 2009年第9期1150-1151,共2页 Chinese Journal of Laboratory Diagnosis
关键词 人肺成纤维细胞 胰岛素样生长因子-Ⅰ 辛伐他汀 human lung fibroblast insulin-like growth factor-1 simvastatin
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