摘要
目的研究辛伐他汀和胰岛素样生长因子-Ⅰ(IGF-Ⅰ)共同对人肺成纤维细胞(HFL-1)增殖的影响。方法培养人肺成纤维细胞,采用MTT法检测在辛伐他汀和IGF-Ⅰ单独/共同作用下对人肺成纤维细胞增殖的影响。结果辛伐他汀和IGF-Ⅰ共同作用于人肺成纤维细胞时,IGF-Ⅰ的促细胞增殖作用受到抑制。结论辛伐他汀可抑制IGF-Ⅰ对人肺成纤维细胞的促增殖作用。
Objective Study on the influences of Simvastatin and IGF-1 on the proliferation of human lung fibroblast.Methods human lung fibroblast was cultured and MTF colorimetry assay was used to determine the proliferation of human lung ftbroblast, the influences of IGF-1 and Simvastatin on the proliferation of human lung fibroblast was observed in vitro.Results The proliferation of human lung fibroblast was inhibited by Simvastatin. Combination of IGF -1 and Simvastatin can inhibit the proliferative capability of human lung fibroblast. Conclusion Simvastatin potently inhibited while IGF-Ⅰ stimulate human lung fibroblast proliferation.
出处
《中国实验诊断学》
北大核心
2009年第9期1150-1151,共2页
Chinese Journal of Laboratory Diagnosis