支气管哮喘患儿治疗前后血清hs-CRP、GM-CSF、IGF-Ⅱ水平检测的临床意义

Clinical significance of determination of changes of serum hs-CRP,GM-CSF and IGF-Ⅱ levels after treatment in pediatric patients with bronchial asthma

目的探讨支气管哮喘患儿的治疗前后血清超敏C-反应蛋白(hs-CRP)、巨噬细胞集落刺激因子(GM-CSF)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)水平变化及意义。方法应用放射免疫法和免疫比浊法对36例支气管哮喘患儿进行血清hs-CRP、GM-CSF、IGF-Ⅱ水平测定,并与35名正常健康儿作比较。结果支气管哮喘患儿治疗前后血清hs-CRP、GM-CSF、IGF-Ⅱ水平均非常显著地高于正常人组(P<0.01)。经治疗后3个月后测与正常儿组比较差异无显著性(P>0.05)。结论检测支气管哮喘患儿治疗前后血清hs-CRP、GM-CSF、IGF-Ⅱ水平的变化对疾病的诊断、治疗和预后的判断均具有十分重要的临床价值。

Objective To explore the changes of serum hs-CRP, GM-CSF and IGF-Ⅱ levels both before and after treat- ment in pediatric patients with bronchial asthma. Methods Serum GM-CSF, IGF--Ⅱ （ with RIA ） and hs-CRP （ with immune turbility ） levels were measured in 36 pediatric patients with bronchial asthma both before and after treatment as well as in 35 controls. Results Before treatment serum hs-CRP, GM-CSF and IGF- II levels were significantly higher in the patients than those in the controls（ P 〈0. O1 ）. 3 months after treatment the levels were not significantly different from those in the controls （ P 〉 O. 05 ）. Conclusion Determination of serum hs-CRP, GM-CSF and IGF-Ⅱ levels in pediatric patients with bronchial asthma is important for diagnosis and outcome prediction.