内毒素及肿瘤坏死因子在大鼠胰源性肺损伤发病过程中的作用及下法对其影响

Research on the pathogenic mechanisms of Acute lung injury induced by endotoxin and tumor necrosis factor in rat model of pancreatic lung injury and therapeutic effect of the purgation herbs

目的：比较观察内毒素及肿瘤坏死因子在胰源性肺损伤动物实验中不同时间的变化及致损作用。方法：在制备胰源性肺损伤大鼠模型基础上，给予通里攻下中药治疗，分设治疗组、造模组、正常对照组，并在三组不同时间检测内毒素及肿瘤坏死因子的含量。结果：治疗组与造模组之间差别显著（Ｐ＜００１），造模组与正常对照组之间差别亦显著（Ｐ＜００１）。结论：内毒素及肿瘤坏死因子参与了胰源性肺损伤的全过程。

bjective:To investigate the injure effect on the tissues and organs in the model of acute pancreatic lung injury induced by endotoxin and tumor necrosis factor.Methods:The acute lung injury(ALT)rat model was made by the peritonealinjection of heterogenous pancreatic tissue smear.The peripherol blood serum of endotoxin and TNF was detected.Results:The serum level of TNF and endotoxin were increased significantly(P<0.01)in the group of ALT rats,and decreased after gastric injection herbs(P<0.01).Conclusion:The purgation herbs can deminate the serm endotoxin and TNF.This herbs has the ability of protecting tissues and organs.