茵陈蒿承气汤配合乳头括约肌切开术治疗急性胆管炎内毒素血症的临床研究

Clinical Study of Therapeutic Effect of Yin Chen Hao Cheng Qi Decoction Combined with Endoscopic Sphincterotomy on Endotoxemia in Acute Cholangitis

为了探讨与分析茵陈蒿承气汤配合内镜乳头括约肌切开术对急性胆管炎内毒素血症的治疗作用机理，将２１例符合乳头切开指征，具有内毒素血症的急性胆管炎患者随机分为切开加中药组（ｎ＝１０）和单纯切开组（ｎ＝１１）。结果与单纯切开组相比，切开加中药组患者外周血中内毒素水平明显降低（治疗后第七日，４７．８０±１１．６２ｐｇ／ｍｌＶＳ３５．９２±８．３０ｐｇ／ｍｌ，Ｐ＜０．０５），丙二醛与Ｃ反应蛋白亦明显下降（Ｐ＜０．０５）；超氧化物歧化酶与补体Ｃ３水平升高显著（Ｐ＜０．０５）。认为茵陈蒿承气汤配合乳头切开治疗急性胆管炎内毒素血症疗效显著。

he effect of Yin Chen Hao Cheng Qi Decoction combined with Endoscopic Sphincterotomy(EST)on endotoxemia in acute cholangitis was observed in order to evaluate the therapeutic mechanism.Twentyone patients with endotoxemia in acute cholangitis underwent EST were divided randomly into two groups:10 of them treated by Yin Chen Hao Cheng Qi decoction with EST(combined therapy group),the other 11 patients were treated with EST(control group alone).The results showed that the level of endotoxin was obviously reduced in the combined therapy group (after 7 days of treatment)47.80±11.62pg/ml VS 35.92±8.30pg/ml,P<0.05),and the level of Malonyldialdehyde and Creactive protein declined obviously(P<0.05);significant increases of Superoxide Dismutase activity and C3level were found in the combined therapy group compared with control(P<0.05).It was suggested that Yin Chen Hao Cheng Qi Decoction combined with EST had a beneficial effect on endotoxemia in acute cholangitis.