苯妥英钠对小鼠骨髓细胞微核率及睾丸染色体畸变率的影响

Effect on Micronucleus Rate of Mice Bone Marrow Cell and Chromosome Aberration Rate in Mice Testicle Cells with Phenytoin Sodium

目的：探讨苯妥英钠的致突变作用。方法：用小鼠骨髓细胞微核试验和小鼠睾丸染色全畸变试验。结果：高浓度苯妥英钠能引起小鼠PCE微核的发生率升高；在睾丸染色体畸变试验中，表现为诱导的小鼠精母细胞染色体畸变率升高。结论：苯妥英钠可能具有致突变作用。

Objective To observe the effectineness of phenytoin sodium as mutagenesis of cyclophospha-mide. Method Mouse bone marrow PCE MN test and mouse orchis chromosome aberration test. Re-sults The PCE MN and rate of orchis chromosome aberration on the group of high concentration of phenytoin sodium was higher than the negative control group,but significant lower than positive control group. Conclusions According to the result we can conclude that phenytoin sodium is a activator with mugenicity or carclnogen.