米非司酮对人蜕膜中雌激素及孕酮受体的影响

Effect of mifepristone on content of estrogen and progesterone receptors in human decidua

本研究观察了服用米非司酮后人蜕膜中雌激素受体（ＥＲ）和孕酮受体（ＰＲ）的变化。６０名孕６～７周的妇女，被随机分为３组。在手术终止妊娠前的１２和２４小时两组中，分别一次性口服米非司酮２００ｍｇ，对照组服用安慰剂。服用米非司酮后，蜕膜中ＥＲ和ＰＲ的免疫组织化学染色反应与对照组比较增强了。卡方分析表明，服用米非司酮后。

bjectives:To examine mifepristone action on decidual estrogen receptor(ER) and Progesterone recptor(PR).Design: Controlled study.Setting: Normal human volunteers in an academic research laboratory.Methods: Immunocytochemical reactions of PR and ER in decidua after mifepristone treatment were compared with the control subjects.Results: Mifepristone treatment increased PR and ER staining in vessel and stroma of decidua.Chisquared analysis indicated a significant increase in the number of ERpositive samples after mifepristone treatment.Conclusion:The decidua was the primary target site of mifepristone.The receptor status changes under effects of antiprogestin.