尼泊金甲酯钠合成工艺研究

Study on Synthesis of Sodium Methylparaben

尼泊金甲酯钠是对羟基苯甲酸甲酯的衍生物,是一种新型的广谱、高效食品及化妆品添加剂.本文通过对羟基苯甲酸甲酯与氢氧化钠反应制备尼泊金甲酯钠.确定影响产品质量的主要因素为研究配料比、温度、加料方式,获得尼泊金甲酯钠的合成最优化条件.该产品含量99.5%,符合药典标准.

Sodium methylparaben, a derivant of methylparaben, is a new type of muhifunctional and high performance food or cometic additive. The preparation of sodium methylparaben by methylparaben and sodium hydroxide as raw materials was studied. The main factors affecting the quality of product were determined by experiments. The optimal reaction conditions for the synthesis of sodium methylparaben were obtained by studying the influence of reagent ration, reaction temperature and methods of feeding materials. The final purity of products reached 99.5% which meeted the pharmacopoeia standards.