CAHPl70透析器复用对血透患者血清补体C3、IL-2、TNF-α、NO的影响

Effect of the Reuse of CAHP170 Dialyzer on Dialysis Membrane Biocompatibility

【目的】探讨CAHPl70透析器复用对透析膜生物相容性的影响。【方法】观察10例维持性血液透析患者在透析器初用和复用时，透前、透析15、120min、透后血清白介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）、补体C3、一氧化氮（NO）的水平。【结果】在透析15min，透析器初用血清IL-2、TNF-α、NO水平较各点显著升高（P〈0．05），复用较初用显著降低（P〈0．05）；血清C3水平则较各点显著降低（P〈0．05），复用较初用显著升高（P〈O．05）；IL-2、TNF-α、NO水平互相呈正相关（P〈0．05），补体C3与IL-2、TNF-α、NO均呈负相关（P〈0．05）。透后血清N0水平较透前显著降低（P〈0．05）。【结论】透析15min时血清IL-2、TNF-α、NO、补体C3水平可作为判断透析器生物相容性的良好指标。透析器复用后透析膜生物相容性得到明显改善。

[Objective] To investigate the biocompatibility of the reuse of CAHP170 dialyzer. [Methods] Ten regular hemodialysis patients were selected. In the first use and reuse of dialyzer, four time points （pre- dialysis, fifteen minutes, two hours, post-dialysis） were chosen to detect the serum IL-2, TNF-α, comple- ment C3 and NO level. [Results] Serum IL 2, TNF-α and NO level increased significantly（ P 〈0.05） and se rum complement C3 level decreased significantly（P〈0.05） at the fifteen minutes after initiation of hemodialy- sis. Compare the first use, the reuse of dailyzer significantly decreased IL-2, TNF-α and NO level （ P 〈0. 05）, but increased complement C3 significantly （ P 〈0.05）. The NO level after dialysis was significantly low- er than that before dialysis （ P 〈0.05）. [Conclusion] On the fifteen minutes of hemodialysis, serum IL-2, TNF-α, complement C3 and NO level are regarded as good markers for membrane biocompatibility. The reuse of hemodialyzer can ameliorate membrane biocompatibility.