血清CA125和β-HCG联合检测在预测输卵管妊娠结局中的价值

Value of the Detection of Serum CA125 and β-HCG for Predicting the Outcome of Tubal Preg- nancy

【目的】通过检测输卵管妊娠患者血清CA125和β-HCG水平，探讨血清CA125和β-HCG在预测输卵管妊娠结局中的价值。【方法】采用电化学发光免疫分析法（ECLIA）检测48例输卵管妊娠流产型（流产组）和17例输卵管妊娠破裂型（破裂组）患者治疗前血清cA125和β-HCG水平，了解两项指标与输卵管妊娠结局之间的关系。【结果】流产组血清cA125水平（41．4u／mL±18．3U／mL）显著高于破裂组血清cA125水平（17．8U／mL±5．7U／mL）（P〈0．001）；流产组血清β-HCG水平（1518．3mIU／mL±669．9mIU／mL）显著低于破裂组血清β-HCG水平（13972．7mIU／mL±9322．2mIU／mL，P〈0．001）。流产组血清CAl25水平与血清β-HCG水平呈线性负相关关系（r=-0．586，P〈0．05）；破裂组血清CA125水平与血清β-HCG水平亦呈线性负相关关系（r=-0．718，P〈0．05）。【结论】①检测血清cAl25水平有助于预测输卵管妊娠的结局。②血清CA125水平随血清β-HCG水平的降低而升高，提示胚胎活性降低。③联合检测血清cA125和β-HCG对临床选择治疗方法有指导意义。

[Objeetive] To determine whether serum CA125 and β-HCG level can be used to predict the outcome of tubal pregnancy. [Methods] Serrum CA125 and β-HCG in 48 patients with tubal abortion and 17 patients with tubal rupture before therapy were measured by the electrochemi[uminescenee immunoassay （ECLIA） to explore the relationships between the two biochemical factors and the outcome of tubal pregnancy. [Results]Serum CA125 level （ 41.4-±18.3 U/mL ） in the patients with tubal abortion was higher than serum that （ 17.8±5.7U/mL ） in the patients with tubal ruptured （ P %0. 001 ）. Serum β-HCG level （ 1518.3± 669.9mlU/mL ） in the patients with tubal abortion was lower than that （ 13972.7 mIU/mL±9322.2 mIU/ mL ） in the patients with tubal ruptured （ P 〈0. 001 ）. There was negative correlation between serum CAt25 and β-HCG （ P 〈0.05） in the two groups. [Conclusion]Serum CA125 level can be used to predict the out- come of tubal pregnancy. Higher serum CA125 and lower serum β-HCG show the decreasing activity of em- bryo. Estimation of serum CA125 combined with serum β-HCG may be, helpful to choose the treatment of tubal pregnancy.