脑钠素与非ST段抬高型心肌梗死冠状动脉病变程度的关系

Value of BNP determination in assessing disease severity in patients with acute myoeardial infarction without ST-segment elevation

目的探讨血浆脑钠素(BNP)与非ST段抬高急性心肌梗死(NSTEMI)患者冠状动脉病变程度的关系。方法研究入选NSTEMI患者81例,均在治疗前采血检查血浆BNP水平,根据BNP中位数将患者分为2组,高BNP组(BNP≥150pg/ml)和低BNP组(BNP<150 pg/ml)。用Judking法对每位患者行冠状动脉造影术(CAG),将其分为正常组、A、B1、B2、C型病变组。结果高BNP组较低BNP组患者冠脉血管病变较重的B、C型病变组人数多,分别为39例(48.5%)和16例(19.8%),差异有统计学意义(P<0.05)。结论NSTEMI患者冠脉病变程度严重者血浆BNP升高,提示血浆BNP是NSTEMI患者冠脉病变程度的重要预测指标。

Objective To investigate the relationship between the plasma level of brain natriuretic peptide（BNP） and disease severity in patients with acute myocardial infarction without ST - segment elevation （NSTEMI）. Methods Eighty - one patients were divided into high BNP group （BNP≥ 150 pg/ml） and low BNP group （BNP 〈 150 pg/ml）. All patients received coronary arteriogra- phy by Judking method, and were divided into normal group, angina groups A, B1, B2, and C. Results Compared with low BNP group, high BNP group had more patiens with type B and C angina[ 39 （48.15%）, 16 （ 19.8% ）, P 〈 0. 05 ]. Conclusions High plasma BNP in patients with NSTEMI is closely related to coronary heart disease severity. BNP is an important index to judge coronary heart disease severity in patients with NSTEMI.