摘要
本文通过调查542例一般健康人(包括长寿老人27例),226例长寿老人,20例80～89岁老人,252例老年高血压病、冠心病、肺心病、糖尿病、自身免疫性疾病及恶性肿瘤疾病患者红细胞内SOD含量,进一步探讨SOD与衰老及长寿的关系。中年期合计组SOD值较青年期合计组值显著降低。而中年组(558±41μg/gHb)与老年组(553±52μg/gHb)间。老年组与老寿组(552±38μg/gHb)间SOD值无明显差异。SOD与诸多生化指标、生理参数及情况无明显相关。故认为将自由基看作是衰老基本原因的自由基学说至少尚未被证明,或仍是可疑的。
SOD contents of RBC were determined by chemical photometric method in 542 healthy individuals including 31 children, 183 youths, 154 adults, 147 elderly,and 27 longevous, with the mean values of 628±36, 587±50, 558±41, 553±52, 552±38μg/gHb respectively. The mean value of SOD of the adults Was significantly lower than that of the youths. The mean value of 22 centenarian's (548±50 μg/gHb) was lower than that of the elderly but stastically not significant. The mean value of the males (573±49μg/gHb) was significantly higher than the females (560±51μg/gHb). No correlation was found between SOD value and many physiological parameters. The mean value of SOD of 252 elderly suffered from hypertension, coronary heart disease, cor pulmonale, diabetes, autoimmune disease and malignant tumor were significantly higher than the healthy individuals.
