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内脂素与冠心病 被引量:11

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摘要 内脂素是一种新的脂肪因子,主要来源于内脏脂肪,具有类胰岛素样作用。近年来的许多研究发现,内脂素与缺氧、易损斑块、内皮功能紊乱、炎症、血管增生等冠心病,尤其动脉粥样硬化的发生和发展过程相关。此外,内脂素还能通过延长氧化应激状态下线粒体渗透转运孔(mPTP)的开放时间,发挥一定的心血管保护作用。
出处 《国际心血管病杂志》 2009年第5期260-263,共4页 International Journal of Cardiovascular Disease
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同被引文献124

  • 1张梅,黄体钢,周丽娟,张一芝,张伟函.炎性因子对急性冠状动脉综合征的早期预测价值[J].临床心血管病杂志,2006,22(3):148-151. 被引量:18
  • 2杨媚,杨刚毅,李伶,李清明,阮华玲,阳皓,李钶,孙勤,唐毅,Gunther Boden.不同糖耐量个体血浆内脂素水平的变化[J].中华内分泌代谢杂志,2006,22(3):245-247. 被引量:76
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33020
  • 4Braunwald E,Antman EM,Beasley JW,et al.ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction.A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines[J].J Am Coll Cardiol,2000,36(3):970-1062.
  • 5冯新成.替罗非班对急性冠脉综合征患者炎症因子的影响.医药与保健,2009,:220-221.
  • 6Adya R,Tan BK,Chen J,et al.Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells:Its role in MMP-2/9 production and activation[J].Diabetes Care,2008,31(4):758-760.
  • 7Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a pro- tein secreted by visceral fat that mimics the effects of insulin [ J]. Science ,2005,307 (5708) :426 - 430.
  • 8Dahl TB, Yndestad A, Skjelland M, et al. Increased expres- sion of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization [ J ]. Circulation ,2007,115 ( 8 ) :972.
  • 9Curat CA, Wegner V, Sengen s C, et al. Macrophages in hu-man viaceral adipose tissue:increased accumulation in obesi- ty and a source of resistin and visfatin [ J ]. Diabetologia, 2006,49 (~) :744 - 747.
  • 10Moschen AR, Kaser A, Enrich B, et al. Visfatin, an adipocy- tokine with proinflammatory and immunomodulating proper- ties[ J 3. J Immuno1,2007,178 (3) : 1748 - 1758.

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