Toll样受体4及Tollip蛋白在大肠癌中的表达及临床意义

Expression of Toll like receptor 4 and Tollip protein in colorectal carcinoma and its clinical significance

目的探讨Toll样受体4(TLR4)及Tollip蛋白在大肠癌发生、发展过程中的作用。方法采用免疫组化SP法检测TLR4和Tollip蛋白在51例大肠癌癌组织和20例癌旁正常组织中的表达,并分析两者与大肠癌临床分期、病理分级的相关性。结果TLR4及Tollip蛋白在大肠癌组织中的表达显著强于癌旁正常组织,且两者表达随肿瘤临床病理分期进展及病理分级降低而升高(P<0.01)。结论TLR4、Tollip蛋白在大肠癌发生、发展过程中发挥一定免疫作用,可作为判断大肠癌进展程度的参考指标。

Objective To investigate the function of Toll like receptor 4 （TLR4）and Tollip protein in the pathogenesis and development of eolorectal carcinoma. Methods The expression of TLR4 and Tollip protein in 51 specimens of colorectal earcinoma and 20 specimens para-tumor tissue were determined by SP immtmohistochemistry method. The relation of the expression of TLR4 and Tollip protein and clinical stages , pathological grades were analyzed. Results The expression of TLR4 and Tollip protein were significantly higher in colorcctal carcinoma tissue than those in para-tumor tissue, and whieh increased with the decrease of clinical stages and pathological grades （ P 〈 0.01 ）. Conclusions The expression of the TLR4 and Tollip protein play immunization in the pathogenesis and development of coloreetal carcinoma,can be used as reference index to estimate the development of colorcctal carcinoma.