摘要
目的探讨肽酰脯氨酰异构酶1(Pin1)与β-连环素在胃癌发生、发展中的作用。方法应用免疫组化SP技术对50例胃癌组织(胃癌组)及30例正常胃组织(对照组)中Pin1、β-连环素表达进行检测,分析两指标间相关性及与胃癌临床病理学特征的关系。结果胃癌组及对照组Pin1表达阳性率分别为24.0%(12/50)、0,β-连环素异常表达率分别为62.0%(31/50)、23.3%(7/30),P均<0.05;Pin1与β-连环素在胃癌组织中的表达密切相关(r=0.51,P<0.01);Pin1及β-连环素表达与胃癌病理分化程度、临床分期、淋巴结转移有关(P<0.05)。结论Pin1和β-连环素异常表达可能在胃癌发生、发展中起重要作用,可作为指导肿瘤治疗及判断转移、预后等的参考指标之一。
Objective To investigate the roles of Pinl and β-catenin in the tumorigenesis and development of gastric carcinoma. Methods The expression of Pinl and β-catenin proteins in 50 cases of gastric cancer tissues （ gastric cancer group） and 30 cases of normal gastric tissues（control group）were detected by immunohistochemistry. The relationships among Pinl and β-catenin expression and clinicopathological factors of gastric carcinoma were analyzed. Results The positive rates of Pinl expression in gastric cancer group and control group were 24% （12/50） ,0（0/30） respectively,the positive rates of β-catenin expression were 62% （31/50） ,23.3% （7/30） respectively,P 〈0.05o There was a significant correlation between Pinl and 13-catenin expression in gastric cancer tissues （r = 0.51 ,P 〈 0.01 ）. The Pinl and β-catenin expression were significantly correlated with pathological grade,clinlcal stage and lymph node metastasis of gastric cancer （P 〈 0.05）. Conclusion The abnormal expression of Pinl and β-catenin may play an important role in the genesis and development of gastric carcinoma, and it may act as the criterions to guide the treatment of carcinoma and judgement of metastasis and prognosis.
出处
《山东医药》
CAS
北大核心
2009年第35期29-31,共3页
Shandong Medical Journal
