国际上治疗心血管病及其相关疾病新药的开发与研究

International development and research of new medicines for cardiovascular diseases and related diseases

对最近几年国际上心血管病的发病及其治疗进行了概述。根据美国药物研究与生产商协会（PhRMA）的新药数据库等对目前国际上270多种用于心血管病及其相关疾病的新药的临床开发研究情况进行归纳、综述和概括,并重点对发病率较高的冠状动脉综合征、动脉粥样硬化、高血压和血栓等疾病的新药开发进行了分析。在开发中用于治疗心血管病的候选药中,进入Ⅰ-Ⅱ期临床试验的数量偏少,已获得批准药品用于新适应证的药物较多,生物技术药物占有一定的比例。

In this paper,we described the international incidence and treatment of cardiovascular diseases in the last few years.More than 270 new medicines are internationally developed to treat and prevent cardiovascular diseases and the related diseases.We reviewed and outlined these medicines based on the Medicines in Development Database created by the Pharmaceutical Research and and Manufacturers of America（PhRMA） and related literature.The new medicines for the treatment of the diseases with higher incidence,such as acute coronary syndrome（ACS）,atherosclerosis,hypertension and thrombosis,are also analyzed and discussed.In conclusion,the number of the new medicines for cardiovascular diseases in Phase I and Phase II is less;many of the new medicines in clinical development are approved as medicines for other diseases;the percentage of biotechnology medicines is very high.