老年高甘油三酯血症患者血清载脂蛋白AⅠ、B、CⅡ、CⅢ_0、CⅢ_1、CⅢ_2含量变化

Changes of Serum Apolipoprotein AⅠ, B, CⅡ, CⅢ_1, and CⅢ_2, Levels in Elderly Patients with Hypertriglyceridemia.

本文测定了35名血脂正常老人和35名老年高甘油三酯血症患者血清载脂蛋白(Apo)AI、B的含量及极低密度脂蛋白(VLDL)和高密度脂蛋白(HDL)分子中ApoCⅡ,CⅢ_0,CⅢ_1,CⅢ_2的百分比。与正常对照组比较.高甘油三酯血症组的ApoB,VLDL-ApoCⅢ_1,CⅢ_2和HDL-ApoCⅢ_1显著增加,ApoAⅠ,HDL-ApoCⅢ_2和VLDL-ApoCⅢ_0显著下降,但ApoCⅡ沒有明显的变化。ApoB、VLDL-ApoCⅢ_1水平与TG呈正相关。ApoAⅠ、VLDL-ApoCⅢ_0水平与TG呈负相关。本文还讨论了ApoAⅠ、B、CⅡ、CⅢ_0、CⅢ_1。

The levels of the Apolipoprotein (Apo) AI, B, and the percentages of the ApoCⅡ, CⅢ_0, CⅢ_1, CⅢ_2, in very low density lipoprotein(VLDL)and ApoCⅡ, CⅢ_1, CⅢ_2 in high density lipoprotein (HDL)have been determined in 35 normolipidemie and 35 hypertriglyceridemic elderly subjects. The levels of ApoB and in the percentages of VLDL-ApoCⅢ_1, CⅢ_2, HDL-ApoCⅢ_1 increased and decreased in the levels of ApoAI and in the percentages of VLDL-ApoCⅢ_0 and HDL-ApoCⅢ_2 in hypertriglyceridemic sera. However, there was no significant variation in proportion of ApoCⅡ in VLDL and HDL.Total serum triglyceride levels correlated positively with ApoB, VLDL-Apo CⅢ_1 and correlated negatively with ApoAI, VLDL-ApoCⅢ_0, The relationship between the variation of ApoAI, B, CⅡ, CⅢ_0, cⅢ_1, CⅢ_2 and pathogenesis of hypertrlglyceridemia has been discussed.