乳腺癌手术中局部应用沙培林的临床观察

Clinical study on local application of sapylin(OK-432) during operation of breast cancer

目的观察乳腺癌患者手术中局部应用沙培林对患者术后恢复的影响。方法随机抽取乳腺癌手术患者81例,观察组42例术中应用沙培林,对照组39例术中不给予沙培林。术后对患者24 h体温变化情况、伤口疼痛时间、伤口引流量及拔除伤口引流管的时间进行比较研究。结果两组伤口疼痛时间、发热等不良事件的发生差异无显著性;观察组伤口引流量较少,拔管时间短。结论乳腺癌术中应用沙培林不良反应少,患者耐受性好。同时能有效减少创面引流量,提早拔除伤口引流管的时间,有利于切口愈合及患者恢复。

Objective To observe the effect of sapylin local application during operation of breast eaneer on post-operative recovery of the patients. Methods A total of 81 patients with breast cancer were randomly divided into two groups. One group was given local application of sapylin during operation. Another group was control group which was not given sapylin. The wound pain, changes of body temperature and the volume of post-operative wound fluid drainage was measured post-operatively and a comparative analysis was carried out. Results The quantity of post-operative wound fluid drainage in the observed group was significantly less than that in the control group and the patients recovered sooner in the sbserved group also. Conclusion Using sapylin during operation of breast cancer is helpful to reducing the volume of post-operative wound fluid drainage and may lead to the patient recovery sooner.