急性冠脉综合征患者血栓调节蛋白水平及临床意义

The clinical significance and level of thrombombdulin in patients with acute coronary syndrome

目的:观察急性冠脉综合征(ACS)患者血栓调节蛋白(TM)水平变化,并结合冠状动脉造影(CAG)结果探讨其临床意义。方法:测定经CAG证实为CHD患者(CHD组,n=56)的TM浓度,且与CAG结果正常组(对照组,n=30)的血浆浓度比较,分析两组间TM浓度的关系及CHD(AP、UAP、AMI)组中TM浓度与冠脉病变程度的关系。结果:对照组、AP组、UAP组、AMI组TM浓度依次增高,分别为(20.24±7.09)、(50.14±8.92)、(69.18±8.12)、(90.19±10.32)pg/L;CAG为单支、双支、三支病变者,其浓度亦依次增高,分别为(50.14±8.92)、(71.34±8.18)、(91.16±9.14)pg/L。结论:CHD患者TM浓度明显升高,且随病变程度加重及冠脉病变范围的扩大而升高。

Objective： To observe the change of thrombombdulin （TM） level and combine with coronary angiography （CAG） results of patients with acute coronary syndrome （ACS） to explore its clinical significance. Methods： The plasma TM concentrations of 56 patients with CHD confirmed by CAG were tested, and were compared with 30 cases of normal control group, the relationship between the TM concentrations of the two groups and different numbers of diseased coronary vessels in CHD （AP, UAP and AMI） group were analyzed. Results： The plasma TM concentrations were （20.24±7.09）, （50.14±8.92）, （69.18±8.12） and （90.19±10.32） pg/L respectively. The plasma TM concentrations were （50.14±8.92）, （71.34±8.18） and （91.16±9.14） pg/L respectively for the one-vessel-disease group, the two-vessel-disease group, and the three-vessel- disease group. Conclusion： The plasma TM concentrations are significantly elevated with the severity of the disease and CAG in patients with CAD.