小剂量酚妥拉明在毛细支气管炎治疗中的应用

Application of the treatment of bronchiolitis by low dose Phentolamine

目的:评估小剂量酚妥拉明治疗毛细支气管炎的疗效。方法:将125例毛细支气管炎住院患儿随机分为三组,即A、B治疗组及对照组C组。三组患儿均采用常规治疗,A治疗组在上述治疗基础上加用酚妥拉明以1.0～1.5μg/(kg·min)静注,B治疗组加用酚妥拉明和多巴胺,酚妥拉明以3～5μg/(kg·min)静注,多巴胺以2～3μg/(kg·min)静注。结果:A、B治疗组的总有效率与对照组比较,有显著性差异,而A、B治疗组间无显著性差异;A、B治疗组间不良反应发生率有显著性差异。结论:酚妥拉明治疗毛细支气管炎的疗效显著,且应采用小剂量。

Objective： To observe the therapeutic effect of bronchiolitis by low dose Phentolamine. Methods： 125 infantile patients of hronehiolitis were randomly divided into three groups, two treated groups （group A, B） and one contrast group （group C）. All infants were treated with conventional therapy. On the basis of conventional therapy, group A was given Phentolamine with 1-1.5 μg/（kg·min）. And on the basis of conventional therapy, group B was given Phentolamine with 3-5 μg/（kg·min） and Dopamine with 2-3 μg/（kg ·min）. Results： There was significant difference between group A, B and contrast group in total effective rate, but there were not predominant differences between group A and group B. In adverse effect rate, group A, B had significant difference. Conclusion： Taking Phentolamine is an effective method to treat bronehiolitis, it should take low dose Phentolamine.