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抗菌药所致获得性QT间期延长综合征的研究现状 被引量:3

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摘要 一些非心脏病药物能够延长心室复极时间(心电图为QT间期延长),即获得性QT间期延长综合征,后者可诱发致命性室性心律失常(如尖端扭转型室速),尤其在药物剂量过大或药物间的药代动力学发生相互干扰时出现。这些药物包括抗精神病药物、H1受体拮抗剂、抗菌药物等。近来一些研究^[1-3]发现,抗菌药物也能导致QT间期延长综合征,现复习有关文献并综述如下:
出处 《中国民康医学》 2009年第18期2294-2294,2328,共2页 Medical Journal of Chinese People’s Health
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参考文献5

  • 1Tisdale JE, Kovacs R, McCabe GP, et al. Accuracy of uncorrected versus corrected QT interval for prediction of torsade de pointes associated with intravenous haloperidol [J]. Pharmacotherapy, 2007,27(2) : 175 - 82.
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同被引文献31

  • 1成建华.非抗心律失常药的致心律失常作用及相关危险因子[J].中国新药与临床杂志,2004,23(10):713-718. 被引量:5
  • 2邓万俊.抗菌药物的心脏毒性[J].中国医院药学杂志,2005,25(3):263-265. 被引量:9
  • 3Bruin ML,Pettersson M,Meyboom RH,et al.Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death[J].Eur Heart J,2005,26(6):590-597.
  • 4Yap YG,Camm AJ.Drug induced QT prolongation and torsades de pointes[J].Heart,2003,89(11):1363-1372.
  • 5Stanat SJ,Carlton CG,Crumb WJ Jr,et al.Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel[J].Mol Cell Biochem,2003,254(12):1-7.
  • 6Abu-Gharbieh E,Vasina V,Poluzzi E,et al.Antibacterial macrolides:a drug class with a complex pharmacological[J].Profile,2004,50(3):211-222.
  • 7Shaffer D,Singer S,Korvick J,et al.Concomitant risk factors in reports of torsades de pointes associated with macrolide use:review of the United States Food and drug administration adverse event reporting system[J].Clin Infect Dis,2002,35(2):197-200.
  • 8Hagiwara T,Satoh S,Kasai Y,et al.A comparative study of the fluoroquinone antibacterial agents on the action potential duration in quinea pig ventricular myocardia[J].Jpn J Pharmacol,2001,87(3):231-234.
  • 9Rubinstein E,Camm J.Cardiotoxicity of fluoroquinolones[J].J Antimicrob Chemother,2002,49(4):593-596.
  • 10Flanagan MC,Mitchell ES,Haigney MC.Ciprofloxacin-induced torsade de points[J].Intern J Cardiol,2006,113(2):239-241.

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