摘要
目的建立在非水溶液中方波伏安法快速检测尼莫地平含量的方法。方法在0.5mol.L-1的高氯酸四丁基铵(tetrabutylammonium perchlorate,TBAP)的乙腈溶液中尼莫地平在铂电极上有一灵敏的氧化峰,利用该峰及方波伏安法(square wave voltammetry,SWV),快速检测尼莫地平含量。结果尼莫地平的浓度在1~2000μg·mL^-1范围内与峰电流呈良好的线性关系,检出限为1μg·mL^-1,平均回收率为99.53%,RSD为0.99%(n=6),检测时间仅需1min。结论该方法可应用于尼莫地平片中尼莫地平含量的测定。方法准确可靠、操作简便、快速、重现性好。
Objective A rapid determination method of Nimodipine has been established by square wave voltammetry (SWV). Methods A sensitive oxidization peak of Nimodipine was obtained in 0. 5mol ·L^-1 tetrabutylammonium perchlorate (TBAP) buffer solution with a platinum electrode as work electrode. Based on it, a rapid determination method of nimodipine has been established by SWV. Results The peak current was directly proportional to the concentration of nimodipine over the range of 1 -2000μg·mL^-1 with the detection limit of 1μg·mL^-1. The average recovery rate was 99.53%, RSD was 0. 99% (n=6). The whole detection time need only one minute. Conclusions This method is applied to the determination of nimodipine in Nimodipine Tablets. It is accurate and dependable, simple, rapid, easily reproducible.
出处
《中国药事》
CAS
2009年第9期875-877,共3页
Chinese Pharmaceutical Affairs
基金
安徽省教育厅自然科学基金(编号2006KJ151B)
安徽省教育厅自然科学基金(编号2006KJ022C)
安徽省教育厅青年教师科研资助计划(编号2005jq1167)
关键词
尼莫地平
电化学行为
方波伏安法
nimodipin
electrochemical behaviours
square wave voltametry