ACE、PAI-1基因多态性与T2DM患者合并冠心病的关系

Relationship between Polymorphisms of PAI-1 Gene,ACE Gene and T2DM Combined with Coronary Heart Disease

目的:探讨血管紧张素转换酶(angiotensin 1-converting enzyme,ACE)基因、纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)基因多态性与2型糖尿病(type 2 diabetes,T2DM)患者冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)的关系。方法:对100例单纯T2DM患者、60例T2DM合并冠心病患者进行ACE基因、PAI-1基因多态性检测,比较两组患者基因型及等位基因分布频率的差异;并进行Logistic多元回归分析影响T2DM患者冠心病的危险因素。结果:冠心病组患者PAI-1基因型频率、4G等位基因频率携带者比例较单纯T2DM患者显著增高(P<0.05)Logistic多元回归分析发现冠心病和PAI-1基因型密切相关。结论:PAI-1基因多态性可能是T2DM患者合并冠心病的危险因素。

Objective：To investigate the relationship between ACE,PAI-1 gene polymorphisms and T2DM with coronary heart disease. Methods ：The polymorphisms of ACE （I/D） gene and PAI-1 （4G/5G） gene in 160 cases were analyzed. Logistic regression analysis was used to disclose the correlation between the CHD and ACE （I/D） and PAI-1 （4G/5G） polymorphisms. Results ：The frequencies of PAI-1 gene type and 4G allele in CHD patients were increased （P〈0.05 ,P〈0. 001 ,respectively）compared with patients with T2DM. In logistic regression analysis ,CHD were related to HbAlc and PAI-1 genotype. Conclusions ：The PAI-1 4G/4G genotype is independent risk factors for CHD withT2DM.