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盐酸雷尼替丁HPMC骨架片药物释放影响因素研究 被引量:2

The Factors Influencing Ranitidine Hydrochloride Release from Hydroxypropylmethylcellulose Matrix Tablet
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摘要 用HPMC为骨架材料,用湿法制粒,将易溶于水的盐酸雷尼替丁制成缓释骨架片,考察HPMC的用量、粘度、湿润剂的浓度,压片压力、片剂大小和亲水性及疏水性辅料对盐酸雷尼替丁缓释骨架片体外释药速率的影响。结果表明盐酸雷尼替丁缓释片的体外释放行为均符合Higuchi方程。HPMC用量、压片压力、片剂大小对盐酸雷尼替丁缓释片的释放速率均有显著性影响;HPMC粘度和用不同浓度乙醇制粒对盐酸雷尼替丁的释放速率影响不明显;亲水性辅料乳糖、PVP-K30和疏水性辅料EC加入均对释药速率有较大影响。 The HPMC matrix tablet of soluble ranitidine hydrocloride(R) was compressed by wet method.Its effect of the amount and viscosity of HPMC,compressing pressure, tablet size and additives on release of the drug from matrix tablets was observed. The results showed that the release behavior of tablets followed Higuchi kinetics. The R release rate was decreased with increasing content of HPMC,tablet hardness and tablet size. The effect of viscosity of HPMC and alcohol content were not significant.The additives of hydrophilic lactose,PVP K 30 and lipophilic EC could affect the R release, and the former could increase the release of the matrix tablet and the later could slow the release.
出处 《中国药科大学学报》 CAS CSCD 北大核心 1998年第4期275-277,共3页 Journal of China Pharmaceutical University
关键词 盐酸雷尼替丁 HPMC 骨架片 药物释放 溃疡病用药 Ranitidine HPMC Matrix tablet Sustained release
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  • 1董志超,国外医药,1993年,14卷,41页
  • 2董志超,药物分析杂志,1993年,13卷,37页

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