上皮性卵巢肿瘤抑制基因nm23的表达

Expression of tumor suppressor gene nm23 in epithelial ovarian neoplasms

应用免疫组化技术ＡＢＣ法检测了５例正常卵巢，２１例腺瘤，１０例交界性肿瘤和４０例卵巢癌及１９例大网膜转移灶等不同阶段组织ｎｍ２３蛋白的表达。结果发现：正常卵巢上皮、腺瘤、交界性肿瘤和卵巢癌组织中ｎｍ２３表达率分别为：２０％、６６６７％、１００％和５０％。交界性肿瘤ｎｍ２３表达同卵巢癌和腺瘤间差别显著（均Ｐ＜００５）。而原发灶和其相应大网膜转移灶ｎｍ２３蛋白表达基本一致。随着卵巢癌组织学级别升高，ｎｍ２３的表达呈下降趋势，Ⅰ级癌ｎｍ２３表达率显著高于Ⅱ、Ⅲ级癌（Ｐ＜００５）。提示：ｎｍ２３基因与卵巢癌的发生有关，并在卵巢癌的细胞分化过程中起调节作用。

Expression of nm23 protein in the tissues of 5 normal ovaries,21 adenomas,10 borderline tumors and 40 ovarian cancers and 19 omental metastatic lesions was determined with immunostaining methods (ABC) at different stages.From normal ovarian epithelia,adenomas,borderline tumors to ovarian cancers,the positive rates of nm23 protein were 20%,66.6%,100% and 50%,respectively,and there was significant differences between borderline tumors and adenomas or ovarian cancers ( P <0.05).However,the expressions of nm23 in the primary lesions and corresponding omental metastatic lesions were almost the same.The positive frequency of nm23 protein decreased with increased malignant grade.The nm23 protein expressed more frequently in grade Ⅰ than in grade Ⅱ and Ⅲ ( P <0.05). It is concluded that nm23 gene takes part in ovarian carcinogenesis and plays a regulatory role in the differentiation of ovarian cancer.