硝酸镧高效催化合成3,4-二氢嘧啶-2(1H)-(硫)酮

Lanthanum Nitrate as An Efficient Catalyst for the Synthesis of 3,4-Dihydropyrimidine-2(1H)-(thio)ones

报道了以La(NO3)3催化芳香醛、β-酮酯和脲或硫脲一锅法合成3,4-二氢嘧啶-2(1H)-(硫)酮的简单、有效方法。与经典Biginelli反应条件相比,它具有产率高、反应时间短和操作简单等优点。所有目标化合物的结构经元素分析、IR、13C NMR和1H NMR确证。

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aromatic aldehydes,β-keto esters and urea or thiourea employing lanthanum nitrate as catalyst is reported. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity. The structures of synthesized titled compounds are confirmed by elemental analysis, IR,13 C NMR and 1 H NMR spectroscopy.