应用ROC曲线评价血浆D-二聚体检测在妊娠高血压综合征诊断中的价值

Clinical evaluation of plasma D-dimer in diagnosis of pregnancy-induced hypertension syndrome by ROC curve analysis

目的：评价血浆D-二聚体检测在妊娠高血压综合征（妊高征）诊断中的价值。方法：分别对妊高征组、非孕对照组、正常妊娠组以及妊高征组中轻度、中度、重度患者的血浆D-二聚体含量进行比较,并应用ROC曲线分析血浆D-二聚体诊断妊高征的曲线下面积、计算诊断点和敏感性、特异性。结果：妊高征组血浆D-二聚体含量显著高于正常妊娠组和非孕对照组,随着病情的增加血浆D-二聚体含量显著增高。血浆D-二聚体诊断妊高征的ROC曲线下面积为0.912（95%C I=0.867-0.957）,诊断点0.88 mg/L诊断妊高征的敏感性为80%,特异性为90%。结论：血浆D-二聚体是诊断妊高征的有效指标。

Objective：To estimate the value of plasma D - dimer in diagnosis of pregnancy - induced hypertension syndrome （PIH）. Methods：The plasma D -dimer level in the patients with PIH, normal pregnant women and normal nonpregnant women were detected. Meanwhile, their results were compared and analysed by ROC curve. Results：The plasma D - dimer level in the patients with PIH strikingly higher than in normal pregnant women and normal nonpregnant women. Furthermore, the significant positive correlation were displayed between plasma D - dimer level and pathogenetic condition of patients with PIH. The area under ROC curve was 0. 912 and the asymptotic 95% confidence interval was （0. 867,0. 957 ） and the sensitivity and specificity were 80% and 90% respectively when 0. 88 mg/L D -dimer was considered as break point to diagnose PIH. Conclusion ：The plasma D - dimer is a effective index for diagnosis of PIH.