罗布麻茶对高脂血症模型大鼠降血脂作用的实验研究

Laboratory study of concentrated tea of apocynum venetum leaf on reducing blood lipid in hyperlipemia model

目的:以高脂血症模型大鼠研究罗布麻茶降血脂功效。方法:采用脂代谢紊乱模型-预防性给受试物法,分别以833.35、1666.7、3333.4 mg/kg BW 3个剂量的罗布麻茶提取液给大鼠连续灌胃30 d,于试验终末采血测定TC、TG、HDL-C含量。结果:受试样品高剂量组大鼠血清胆固醇(TC)含量为(1.94±0.31)mmol/L、甘油三酯(TG)含量为(0.94±0.16)mmol/L、高密度脂蛋白胆固醇(HDL-C)含量为(1.08±0.11)mmol/L,均低于高脂对照组的TC含量(2.41±0.27)mmol/L、TG含量(1.31±0.28)mmol/L,高于高脂对照组的HDL-C含量(0.87±0.17)mmol/L,差异均具有非常显著性(P<0.01)。结论:该罗布麻茶能降低大鼠血清总胆固醇、血清甘油三酯含量,升高高密度脂蛋白胆固醇的含量,提示该样品具有降血脂的功效。

Objective： To explore the effect of the concentrated tea of apocynum venetum leaf on reducing blood lipid in hyperlipemia model rats. Methods ： The model of metabolic disturbance of lipid - preventive tested sample was adopted. After being given apocynum tea extract in dosages of 833.35, 1666. 7, 3333.4 mg/kg BW respectively for 30 days, the contents of total cholesterol （TC）, triglyceride （TG） and high -density lipoprotein cholesterol levels （HDL- C） in serum of rats were tested. Results： The contents of TC, TG and HDL - C in high dosage group were （ 1.94± 0. 31 ）, （ 0. 94± 0. 16 ） and （ 1.08± 0. 11 ） mmol/L respectively, were lower than the TC content （2.41 ±0. 27） mmol/L and TG content （ 1.31±0. 28） mmol/L and higher than HDL -C concentration of （0. 87 ±0. 17） mmol/L in high -fat control group, the differences were very significant （P 〈0.01 ）. Conclusion ：The concentrated tea of apocynum venetum leaf can reduce the contents of serum total cholesterol, serum triglyceride and increase high -density lipoprotein cholesterol levels. It suggests that the sample has a hypolipidemic effect.