1Pang M, Martinez A F, Fernandez I, et al. AP1 stimulates the cathepsin K promoter in RAW 264. 7 cells [J]. Gene, 2007, 403: 151-158.
2Motyckova G, Weilbaecher K N, Horstmann M, et al. Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family [J]. Proc NatlAcadSciUSA, 2001, 98:5798-5803.
3Lecaille F, Bromme D, Lalmanach G. Biochemical properties and regulation of cathepsin K activity [J]. Biochimie, 2008, 90: 208-226.
4Atley L, Mort J S, Lalumiere M, et al. Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating by cross-linked N-telopeptide neoepitope [J]. Bone, 2000, 26:241-247.
5Sassi M L. Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K [J]. Bone, 2000,26: 367-373.
6Troen B R. The regulation of cathepsin K gene expression [J]. AnnNYAcadSci, 2006,1068:165-172.
7Matsumoto M, Kogawa M, Wada S. Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATcl and PU.I[J]. J Biol Chem, 2004, 279: 45969-45979.
8Im S H, Rao A. Activation and deactivation of gene expression by Ca^2+/calcineurin-NFAT-mediated signaling [J]. Mol Cells, 2004,18: 1-9.
9Furuyama N, Fujisawa Y. Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts [J]. Steroids, 2000, 65: 371-378.
10Kamolmatyakul S, Chen W, Li Y P. Interferon-gamma down- regulates gene expression of cathepsin K in osteoclasts and inhibitsosteoclast formation [J]. J Dent Res, 2001,80: 351- 355.
6Livak KJ,Schmittgen TD.Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method[J].Methods,2001,25(4):402-408.
7Troen BR.Molecular mechanisms underlying osteoclast formation and activation[J].Exp Gerontol,2003,38(6):605-614.
8Sugimori K,Matsui K,Motomura H,et al.BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt mediated NF-kappaB activation[J].J Bone Miner Metab,2005,23(6):411-419.
9Liu X,Bmxvoort KJ,Zylstra CR,et al.Lifelong accumulation of bone in mice lacking Pten in osteoblasts[J].Proc Natl Acad Sci U S A,2007,104(7):2259-2264.
10Hanada M,Feng J,Hemmings BA.Structure,regulation and function of PKB/AKT-a major therapeutic target[J].Biochim Biophys Acta,2004,1697(1-2):3-16.