门冬氨酸阿奇霉素治疗儿童下呼吸道感染的疗效分析

Analysis the clinical efficiency about Azithromycin AspartateforInjection treatment of children with lower respiratory infection

目的 探讨门冬氨酸阿奇霉素治疗儿童细菌性下呼吸道感染的可行性及安全性。方法我院注射用门冬氨酸阿奇霉素治疗下呼吸道感染儿童166例。门冬氨酸阿奇霉素剂量按每天10mg／kg，加入葡萄糖液中1～3h静脉慢滴，疗程3～7d。观察治疗前后症状、体征变化，以及外周血、肝功能、肾功能及X线胸片变化，并取痰液作培养及门冬氨酸阿奇霉素药敏试验，或取痰液及血清进行非典型病原菌抗原抗体检测。结果治愈55例，显效67例，好转11例，无效33例，总有效率为73．5％，18例（10．8％）发生不良反应，其中纳差16例，恶心2例，不良反应1d后消失。2例治疗前血清转氨酶为48U／L、56U／L（正常值〈40U／L），治疗后患儿下呼吸道感染痊愈，肝功恢复正常。结论门冬氨酸阿奇霉素对儿童细菌性下呼吸道感染疗效较好，安全性高。

Objective To explored the practicality and safety that azithromycin aspartateforInjection treats children with lower respiratory infection Methods 166 case of children with lower respiratory infection were treated by azithromycin aspartateforInjection injected. Azithromycin aspartateforInjection 10ml/kg per day added into glucose solution in vein by slow drops for 1 -3 hours and kept on 3-7 days. Before and after the therapy were compared the clinical symptoms, signs,peripheral blood, liver and kidney functions and the change of chest X-ray. Sputum bacterial culture and drug sensitive test of azithromycin aspartateforlnjection were performed. Or detected atypical pathogenicbacteria in sputum and serum. Results Cured 55 cases,effective in 67 cases, improvement in 11 eases, 33 cases ineffective, the total effective rate was 73. 5% , 18 cases （ 10. 8% ） occurring adverse reactions, including 16 eases of anorexia, nausea in 2 cases, adverse reactions disappear after one day. Before the therapy,2 cases of pre-treatment serum transaminase 48U/L,56U/L （Normal 〈 40U/L） ;after it, the children with lower respiratory infection were healed and their live functions recovered. Conclusion The treatment of azithromycin aspartateforlnjection on children with ower respiratory infection was practical and safe.