摘要
目的研究CXCR4和MMP-2在卵巢上皮性肿瘤中的表达情况及临床意义。方法应用免疫组织化学方法检测正常卵巢组织、良性上皮性卵巢瘤、卵巢癌、卵巢癌盆腔腹膜转移灶中CXCR4和MMP-2的表达,分析其与卵巢癌生物学特征之间的关系。结果CXCR4在卵巢癌及转移灶中的阳性率分别为60%、77.8%,明显高于正常卵巢组织(0)及卵巢良性肿瘤(0);MMP-2在卵巢癌及转移灶中阳性率分别为85%、100%,明显高于正常卵巢组织(20%)及卵巢良性肿瘤(30%)(P均<0.05)。两者的表达呈正相关。结论CXCR4和MMP-2在卵巢癌中表达明显上调,可能在卵巢癌发生发展过程中起重要作用。
Objective To evaluate the expression of CXCR4 and MMP-2 in human ovarian tumors and to analyze the clinical significance. Methods Expression of CXCR4 and MMP2 were examined by Immuno- histochemistry in normal ovarian tissues, benign ovarian tumors, malignant ovarian carcinoma and perito- neal metastasis. The relationship between expression and biologic characteristic of ovarian carcinoma was analyzed. Results The positive expression of CXCR4 in ovarian cancer was 60%, in peritoneal metastasis 77. 8%,which were higher than those in normal ovarian tissues and benign ovarian tumors. The positive expression of MMP2 in ovarian cancer was 85 %, in peritoneal metastasis 100 %, which were higher than those in the normal ovarian tissues and benign ovarian tumors . The differences were significant（P〈 0. 05） . The expression of these two proteins were correlated（P〈0. 05）. Conclusion CXCR4 and MMP- 2 may play great roles in the origin and progression of ovarian carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2009年第9期747-749,共3页
Cancer Research on Prevention and Treatment
基金
河北省教育厅科学研究计划资助项目(2008139)
