福建省大肠癌发病危险因素的病例对照研究

Case-control Study on Risk Factors of Colorectal Cancer in Fujian Province

目的探讨福建省大肠癌发生的危险因素。方法采用1∶1匹配的病例对照研究方法,应用统一制订的调查表进行流行病学调查。共调查286对病例和对照。对资料进行单因素和多因素条件Lo-gistic回归分析。结果大肠癌的危险因素有饮用井水(OR=4.05,95%CI:1.50～10.94)和泉水(OR=7.73,95%CI:2.02～29.54),每天吸烟量(OR=4.57,95%CI:2.19～9.54),油腻饮食(OR=5.35,95%CI:2.21～12.99),肿瘤家族史(OR=6.18,95%CI:3.05～12.51),肠道疾病史(OR=6.78,95%CI:3.53～13.07);保护因素有常吃粗粮(OR=0.31,95%CI:0.17～0.53)。结论福建省大肠癌与吸烟,膳食纤维缺乏,饮用井水、泉水,下消化道疾病和肿瘤家族史密切相关。

Objective To investigate the potential risk and protective factors of colorectal cancer in Fujian province. Methods A 1 ： 1 matched case-control study was conducted, which included 286 pairs cases and controls. Standard questionnaire were used in collecting epedemiological factors. The data were ana- lyzed by conditional Logistic regression model. Results Increased risk of colorectal cancer was associated with well water drinking （ OR = 4. 05,95 % CI： 1.50 -10. 94）, spring water drinking （OR = 7. 73,95 % CI： 2. 02-29. 54）, cigarette smoking （OR = 4. 57,95 % CI：2. 19 - 9. 54）, intaking greasy food （OR = 5.35, 95%CI：2. 21-12. 99）,family history of tumor（OR = 6. 18,95%CI： 3.05-12. 51 ）, and disease history of lower digestive tract. Often intaking of coarse food grains decreased the risk of colorectal cancer（OR = 0. 31,95%CI：0. 17-0. 53）. Conclusion The occurrence of eolorectal cancer seemed to be related with cigarette smoking, deficiency of dietary fiber, drinking well-water and spring-water, intaking greasy food, disease history of lower digestive tract and family history of tumor.