期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

前列腺癌中TGF-β/Smad信号的研究进展 被引量：1

TGF-β/Smad in Prostate Cancer:An Update
下载PDF
导出
摘要 转移生长因子β(TGF-β)超家族的成员及其下游的Smad信号转导分子与肿瘤的发生与发展有密切关系。在前列腺癌中,TGF-β/Smad信号通路被激活,在细胞水平调节细胞粘附性、肌丝系统、细胞周期等方面,并在分子水平调节特异基因的表达。同时其他的信号通路如MAPK和PI3K/Akt/mTOR通路以及一些基因和蛋白分子对于TGF-β/Smad信号通路的表达也具有调控作用。本文对近年来前列腺癌中关于TGF-β及Smad信号的表达、作用及调控方面的研究进展作一综述,并对其在前列腺癌基础研究与靶点治疗中的意义作一展望。 Tumorigenesis and cancer progression are closely associated with the transforming growth factor-β （TGF-β） and its downstream component Smad. The TGF-β/Smad signaling pathway, which is activated in prostate cancer, has a regulatory effect on cell adhesion, the actin filament system and cell cycle, as well as the expression of specific genes. Meanwhile, other protein signals such as MAPK and PI3K/Akt/mTOR and some genes may act on the expression of the TGF-β/Smad pathway. This article updates recent researches on the expression, action and regulatory effect of the TGF-β/Smad signaling pathway in prostate cancer.
作者 查佶 黄宇烽
机构地区 南京大学医学院临床学院/南京军区南京总医院解放军临床检验医学研究所
出处 《中华男科学杂志》 CAS CSCD 北大核心 2009年第9期840-843,共4页 National Journal of Andrology
关键词 转移生长因子 SMAD 前列腺癌 transforming growth factor Smad prostate cancer
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献32

  • 1Zhu B, Kyprianou N. Transforming growth factor beta and prostate cancer. Cancer Treat Res, 2005, 126: 157-173.
  • 2Sheehan GM, Kallakury BV, Sheehan CE, et al. Smad4 protein expression correlates with grade, stage, and DNA ploidy in prostatic adenocarcinomas. Hum Pathol, 2005, 36 ( 11 ) : 1204- 1209.
  • 3Kaminska B, Wesolowska A, Danilkiewicz M. TGF beta signalling and its role in tumour pathogenesis. Acta Biochim Pol, 2005, 52(2) : 329-337.
  • 4Baselga J, Rothenberg ML, T abernero J, et al. TGF-beta signalling-related markers in cancer patients with bone metastasis. Bi omarkers, 2008, 13(2) : 217-236.
  • 5Lu S, Lee J, Revelo M, et al. Smad3 is overexpressed in advanced human prostate cancer and necessry for progressive growth of prostate cancer cells in nude mice. Clin Cancer Res, 2007, 13 (19) : 5692-5702.
  • 6Perttu MC, Martikainen PM, Huhtala HS, et al. Altered levels of Smad2 and Smad4 are associated with human prostate carcinogenesis. Prostate Cancer Prostatic Dis, 2006, 9(2) : 185-189.
  • 7Brodin G, ten Dijke P, Funa K, et al. Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration. Cancer Res, 1999, 59 (11 ) : 2731-2738.
  • 8李泽良,杨野,李振华,孔垂泽.前列腺癌组织中TGF-β1 mRNA表达及其临床意义[J].中华男科学杂志,2005,11(7):511-513. 被引量：5
  • 9Hayes SA, Zamegar M, Sharma M, et al. SMAD3 represses androgen receptor-mediated transcription. Cancer Res, 2001, 61 (5) : 2112-2118.
  • 10Hayes SA, Huang X, Kambhampati S, et al. p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion. Oncogene, 2003, 22(31): 4841-4850.

二级参考文献14

  • 1Ilio KY, Sensibar JA, Lee C. Effect of TGF-betal, TGF-alpha and EGF on cell proliferation and cell death in rat ventral prostatic epithelial cells in culture[J]. J Androl, 1995, 16(6): 482-490.
  • 2Wilding G. Response of prostate cancer cells to peptide growth factors: transforming growth factor-beta [ J ]. Cancer Surv, 1991,11: 147-163.
  • 3Pasche B. Role of transforming growth factor beta in cancer[ J ]. J Cell Physiol, 2001, 186(2): 153-168.
  • 4Bronzert DA, Bates SE, Sheridan JP, et al. Transforming growth factor-beta induces platelet-derived growth factor (PDGF) messenger RNA and PDGF secretion while inhibiting growth in normal human mammary epithelial cells[J]. Mol Endocrinol, 1990, 4(7): 981-989.
  • 5Derynck R, Feng XH. TGF-beta receptor signaling[ J]. Biochim Biophys Acta, 1997, 1333(2): F105-F150.
  • 6Martikainen P, Kyprianou N, Isaacs JT, et al. Effect of transforming growth factor-betal on proliferation and death of rat prostatic cells[ J]. Endocrinology, 1990, 127 (6): 2963-2968.
  • 7Wikstrom P, Damber J, Bergh A. Role of transforming growth factor-betal in prostate cancer [ J]. Microsc Res Tech, 2001,52(4): 411-419.
  • 8Wrana JL, Attisano L, Wieser R, et al. Mechanism of activation of the TGF-beta receptor [ J ]. Nature, 1994, 370 (6488): 341-347.
  • 9Massague J, Chen YG. Controlling TGF-beta signaling[J]. Genes Dev, 2000, 14(6): 627-644.
  • 10Kretzschmar M, Liu F, Hata A, et al. The TGF-beta family mediator smadl is phosphorylated directly and activated functionally by the BMP receptor kinase[ J]. Genes Dev, 1997, 11 (8): 984-995.

共引文献4

同被引文献8

引证文献1

二级引证文献4

中华男科学杂志
2009年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部