溪黄草对代谢综合征患者血栓前状态及前炎性状态标志物的作用

Effect of Isodon.serra(Maxim) Kudo against the Markers of Prekronbotic state and Preimflammation state in Metabolize syndrome

【目的】探讨溪黄草对代谢综合征患者血栓前状态及前炎性状态标志物的作用。【方法】选择代谢综合征血栓前状态及前炎性状态标志物异常患者100例,按区组随机法分成2组,每组50例,健康对照组50例。Ⅰ组和Ⅱ组每次均用溪黄草5g加凉开水60mL,保持50～60℃浸泡1h后饮服,连服28d,Ⅰ组每日服1次;Ⅱ组每日服2次,上下午各1次。Ⅰ组和Ⅱ组分别于治疗前1d、治疗后29d查ET、VwF、GMP-140、DD、hs-CRP和肝肾功能,治疗后第7、14、21天查肝肾功能。对照组于入选时查ET、VwF、GMP-140、DD、hs-CRP。2个治疗组治疗前分别与空白对照组比较,2个治疗组治疗前后分别比较、组间分别比较。【结果】①治疗组Ⅰ和治疗组Ⅱ治疗前的ET、VwF、GMP-140、DD及hs-CRP分别与空白对照组对比,差异有显著性(P均﹤0.01)。②治疗组Ⅰ和治疗组Ⅱ治疗前后的ET、VwF、GMP-140、DD及hs-CRP对比,差异有统计学意义(P均﹤0.05)。③治疗组Ⅰ与治疗组Ⅱ治疗后组间的ET、VwF、GMP-140、DD及hs-CRP对比,有差异但无有统计学意义(P均﹥0.05)。【结论】溪黄草可改善代谢综合征患者血栓前状态及前炎性状态。

[Objective] To evaluate the effect of Isodon.serra （Maxim）Kudo against the markers of Prekronbotic state and Preimflammation state in Metabolize syndrome. [ Methods] 100 patients with the abnormal markers of Prekronbotic state and Preimflammation state in Metabolize syndrome were randomized to treatment group Ⅰ （Group Ⅰ , n=50） and treatment group Ⅱ （Group Ⅱ, n = 50）. they ＆inked with Isodon.serra（Maxim） Kudo 5 g with 50-60 degrees 50 mL water soaking water after 60 minutes for 28 days （Group Ⅰ q.d,Groups Ⅱ b.i.d）. Healthy controls （Groups Ⅲ,n = 50） without treatment,another. The groupsⅠ and Ⅱ were detected plasma ET,VwF,GMP-140,DD,hs-CRP,ALT,AST and BNU in the day before treatment and 29^st day after treatment,also were detected plasma ALT, AST and BUN in 7^st, 14^st, and 21^st day after treatment, respecitely. [Results] ①It has remarkable difference that the all levels of plasma ET,VwF,GMP-140,DD and hs-CRP before treatment in groups Ⅰ and Ⅱ compared with its in Groups Ⅲ （P 〈 0.01 ）, respecitively. ②It has remarkable difference that the all levels of plasma ET, VwF, GMP-140,DD and hs-CRP before treatment compared with its after treatment（P 〈 0.05） in groups Ⅰ and Ⅱ ,respecitely. ③There were no remarkable difference for the all levels of plasma ET,VwF,GMP-140,DD and hs-CRP after treatment between groups Ⅰ and Ⅱ （P 〉 0.05）, respecitively. [Conclusion] Isodon.serra （Maxim） Kudo can improve the markers of prekronbotic state and preimflammation state in metabolize syndrome.