胃癌组织中VEGF、CD105表达与预后的关系

Expression of VEGF,CD105 in gastric cancer and its correlation with prognosis

目的:探讨VEGF、CD105在胃癌组织中的表达及临床意义。方法:采用免疫组织化学法检测53例胃癌组织中VEGF、CD105表达,探讨其与临床病理特征及预后之间的关系。结果:胃癌组织中VEGF的表达率是60.5%,VEGF的表达与临床分期、淋巴结转移有关,与性别、年龄、肿瘤分化程度无关。VEGF阳性表达的病人总生存率比阴性表达者低。结论:VEGF表达水平异常增高在胃癌的发生发展过程中起重要作用,检测VEGF、CD105表达水平可判断胃癌病人预后及为术后辅助治疗提供参考依据。

Objective：To study the expression of VEGF, CD105 in gastric cancer tissues and its correlation with prognosis. Methods： The expression of VEGF, CD105 were detected in 53 gastric carcinoma samples by immunohistochemical method. Results： The expression rate of VEGF was 60.3 % , and closely related to the lymph node metastasis and TNM stage（ P 〈 0.05 ）, but not to histological differentiation, gender and age. There was significant difference in disease free survival or overall survival between the gastric cancer patients with positive and negative expression. Conclusion： The expression level of VEGF, CD105 may serve as a prognostic marker and guide the postoperation adjuvant therapy for gastric cancer patients.