组织工程技术在泌尿外科的应用进展

Current status of tissue engineering in urology

组织工程技术为泌尿外科临床医师提供了一条修复乃至重建受损脏器的新途径。组织工程再造阴茎海绵体技术已成功应用于动物模型;利用组织工程产物进行尿道下裂重建在临床上已获得肯定的疗效;膀胱组织工程技术的临床应用也已进入临床Ⅱ期试验阶段。随着新血液透析装置的临床应用,腹腔内人工肾脏替代可能成为现实。该文就目前组织工程技术在泌尿外科的临床应用现状进行综述。

Tissue engineering provides urologists a new way to fix or reconstruct the impaired organs.Reconstitution of corporal bodies of penis with engineered tissue substitutes has been applied in animal models.In hypospadias reconstruction,the use of engineered tissue substitutes has been applied clinically.The clinical application of bladder tissue substitutes has been ongoing phase II clinical trial.Great progress has been made in renal replacement therapy with clinical application of human progenitor cells in hemofiltration units,and the engineered intracorporeal renal replacement unit will come true by additional studies.The current status of tissue engineering in clinical practice of urology is reviewed in this paper.