羟基磷灰石人工骨应用于MSCS后路手术的临床研究

Clinical Research on Coralline Hydroxyapatite for the Treatment of MSCS

【目的】观察羟基磷灰石人工骨应用于多节段脊髓型颈椎病(MSCS)后路手术的效果,比较羟基磷灰石人工骨与自体骨的差异。【方法】实施颈椎后路棘突纵切双开门椎管扩大成形术治疗MSCS85例,其中采用自体骨23例,其余62例采用羟基磷灰石人工骨。对比观察手术前后JOA评分及手术用时、术中出血量。【结果】85例患者术后随访>3个月。两组间手术前后JOA评分比较无显著性意义(P>0.05)。采用羟基磷灰石人工骨组手术用时65～110min,平均85.2min;采用自体骨组手术用时75～150min,平均116.4min。采用羟基磷灰石人工骨组术中出血量130～400mL,平均210mL;采用自体骨组手术出血量170～500mL,平均260mL。采用羟基磷灰石人工骨组除3例有羟基磷灰石碎裂外,未发生材料宿主反应及其他严重并发症。【结论】羟基磷灰石人工骨用于治疗MSCS后路手术的效果好,并发症少;手术用时及出血量少。

[Objective] To study clinical results on Coralline hydroxyapatite for the treatment of MSCS, to compare the different between Coralline hydroxyapatite and autogenous bone. [Method] There were 62 cases in this series, 23 cases were treated with thoracic tuberculosis and 62 cases were treated with autogenous bone. To explore the JOA scores, the times of operation in and the blood loss in the treatment of MSCS, to compare the different between Coralline hydroxyapatite and autogenous bone. [Results] The follow-up period was over 3 months. There were no significant differences between the two sets in the JOA scores （P 〉0.05）. The times of operation with thoracic tuberculosis were 65 to 115 rain （average： 85.2 min）, and the times of operation with autogenous bone were 75 to 150 min （average： 116.4 rain）. The blood loss in operation with thoracic tuberculosis was 130 to 400 mL （average： 210 mL）, and the blood loss in operation with autogenous bone was 170 to 500 mL （average： 260 mL）.Beside 3 cases appeared smash, no host rejection or complications were found in which treated with thoracic tuberculosis. [Conclusions] Coralline hydroxyapatite was applied to the treatment of MSCS. It has fine indication and few complications. It can reduce the times of operation and the blood loss.