摘要
【目的】观察布托啡诺预处理对体外循环冠脉搭桥(CABG)患者的心肌保护作用。【方法】选择24例行CABG的冠心病患者,随机分为布托啡诺预处理组(B组)和对照组(C组)。测定术前、术毕及术后1 h、6 h、24 h、48 h血清cTnI水平。【结果】各组内术后cTnI水平均明显增高(P<0.05)。R组术后cTnI水平显著低于C组(P<0.05)。【结论】布托啡诺预处理可降低CABG患者的cTnI水平,具心肌保护作用。
[Objective] To investigate the protective effect of butorphanol precondition against myocardial injury induced by CABG. [Methods] Twenty-four patients undergoing CABG were randomly divided into two groups (n = 12): control group and butorphanol preconditioning group. Blood samples were obtained prior of the operation and at the 0,2,6,24,48 h after the end of the operation. The serum cTnl were determined. [ Results] In every group, the cTnI levels were significantly increased at the postoperative (0,2,6,24,48 h) compared with those before the operation (P 〈 0.05). The cTnI levels of B-group were markedly decreased compare with those of C-group after the operation(P 〈 0.05). [Conclusion] butorphanol precondition decreases the cTnI levels induced by CABG.
出处
《中山大学学报(医学科学版)》
CAS
CSCD
北大核心
2009年第A04期180-182,共3页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省科技计划项目(2007B030704005
2007B031500002)