颐年降压饮治疗早期原发性高血压患者40例临床观察

Clinical Observation on 40 Early Primary Hypertension Patients Treated by Yinian Jiangya Yin

目的观察颐年降压饮治疗早期高血压病患者临床疗效及其在血管内皮细胞功能方面的作用机制。方法选取早期原发性高血压中医证属痰瘀阻络、肝阳偏亢型患者79例,随机分为治疗组40例与对照组39例,分别给予颐年降压饮和天麻钩藤饮进行治疗,观察治疗前后两组中医证候积分和血压的变化,治疗后测定患者血清一氧化氮(NO)、内皮素(ET)的含量。结果治疗组中医证候积分、降压疗效与对照组比较有统计学差异(P<0.05),治疗后两组患者血清ET、NO含量比较亦有统计学差异(P<0.05)。结论颐年降压饮具有改善早期原发性高血压患者中医证候、降低血压等疗效,可能与其调节ET、NO失衡,进而恢复血管内皮依赖性舒张功能有关。

Objective To observe the clinical effect of Yinian Jiangya Yin （Decoction for prolonging life and lowering blood pressure） on early primary hypertension patients and to explore its functional mechanism on vascular endothelial cells. Methods Totally 79 patients with early primary hypertension belonging to the TCM syndrome of phlegm and blood stasis in meridians and hyperactivity of liver yang were randomized into a treatment group （n= 40） and a control group （n=39）. The treatment group was treated with Yinian Jiangya Yin while the control group treated with Tianma Gouteng Yin （Gastrodia-Uncaria Decoction）. The changes in TCM syndrome scores and blood pressure after treatment were observed and the serum nitrogen oxide （NO） and endothelin （ET） were measured after treatment. Results Compared with the control group, the significant difference existed in the scores of TCM syndrome and the effect on lowering blood pressure in the treatment group （P〈0.05）. After treatment, the significant difference existed in ET and NO of two groups （P〈0.05）. Conclusion Yinian Jiangya Yin is effective in promoting the TCM symptoms and lowering blood pressure. This may relate to its function of regulating ET and NO to restore the endothelium-dependent vasodilation.