肉桂对哮喘模型豚鼠血清中IL-25、的影响

Effects of Cortex Cinnamomi on Serum Levels of Interleukin-2 and Interleukin-5 in Asthma Guinea Pigs

目的:观察肉桂对哮喘模型豚鼠血清中IL-2、5的影响,探讨肉桂平喘的作用机制,以期为临床用药提供理论支持。方法:参照文献构建豚鼠哮喘复合肾阳虚模型,以氨茶碱为阳性对照药,分别以放射免疫方法和ELISA法检测豚鼠血清中IL-2、5的变化。结果:肉桂各剂量组能明显降低血清中IL-25、的含量(P<0.05)。结论:肉桂平喘的作用机制可能在于降低血清中IL-2含量,使IL-5合成减弱,进而使炎症细胞部位嗜酸粒细胞、淋巴细胞等减少,减缓气道慢性炎症形成。

Aim：To observe the effect of cassia on IL-2 and IL-5 in asthma model guinea pig serum, and to study the mechanism of cassia stoping asthma action, which would be wish to provide theory support for clinical medication. Methods： To construct guinea pig asthma and insufficiency of kidney-YANG model. Aminophylline was positive control drug. To detect the variation of IL-2 and IL-5 in guinea pig serum by radio- immunity means and ELISA means. Results ： The every dose group of cassia could reduce obviously the content of IL-2 and IL-5 in guinea pig serum（ P 〈 0.05）. Conclusion：Cassia reduced the variation of IL-2 in guinea pig serum, which weakened the synthesis of IL-5. Inflammatory cell reduced such as EOS and Lc. Chronic inflammation of air tube slow down. This maybe the mechanism of action of cassia relieving asthma.