1567例性传播疾病患者单纯疱疹病毒Ⅱ型病毒感染的临床分析

Clinical study of herpes simplex virus type Ⅱ infection in 1567 patients with sexually transmitted diseases

目的观察性传播疾病(STD)中单纯疱疹病毒Ⅱ型(HSV-Ⅱ)临床感染情况。方法对1 567例患有STD的患者进行泌尿生殖道分泌物HSV-ⅡDNA检测。结果1 567例STD患者中HSV-ⅡDNA阳性为398例占25.40%,其中男性阳性率26.60%(216/812),女性阳性率24.11%(182/755)。泌尿生殖道有明显溃疡的427例中HSV-ⅡDNA阳性320例阳性率74.94%,1 140例无溃疡中HSV-ⅡDNA阳性78例,阳性率6.84%。结论在STD感染患者中HSV-Ⅱ感染较为常见。泌尿生殖道无溃疡的STD患者中仍存在HSV-Ⅱ病毒的感染。荧光PCR技术检测HSV-Ⅱ感染有较好的临床应用价值,值得临床推广。

Objective To investigate the prevalence of herpes simplex virus type Ⅱ （HSV-Ⅱ） infection in patients with sexually transmitted diseases （STD）. Methods A real-time polymerase chain reaction （PCR） was performed with specific primers to detect HSV-Ⅱ in the genitourinary tract secretion specimens from 1 567 patients with STD. Results The prevalence of HSV-Ⅱ infection was 25.40% （398） in 1 567 genitourinary tract secretion specimens, and was 26. 60% in 812 male STD patients, 24. 11% in 755 female STD patients. For 427 STD patients with definite genitourinary tract ulcers and 1 140 STD patients without genitourinary tract ulcers, the prevalence rates of HSV-Ⅱ infection were 74. 94% （320） and 6. 84% （78）, respectively. Conclusion HSV-Ⅱ infection is eommon in STD patients. STD patients without genitourinary tract ulcers still remain the possibility of HSV-Ⅱ infection. A real-time PCR assay can sensitively detect HSV-Ⅱ DNA. It deserves clinical expansion.