小剂量干扰素α联合多抗甲素治疗麻疹的疗效

Therapeutic Effects of Interferon-α and Polyresistin on Measles in Children

目的探讨干扰素α(IFN-α)联合多抗甲素治疗小儿麻疹的疗效及安全性。方法选择2000年1月-2002年6月及2007年1月-2008年2月首都儿科研究所附属儿童医院感染科112例经血清ELISA方法检测麻疹抗体阳性的麻疹患儿。其中男62例,女50例;年龄0～3岁70例(62.5%),>3～6岁24例(21.4%),>6～10岁11例(9.8%),>10～15岁7例(6.3%)。随机分成治疗组和对照组。治疗组60例给予IFN-α,≤3岁10万U/d,>3岁20万U/d;联合多抗甲素,≤3岁2.5 mg/次,>3岁5.0 mg/次,3次/d,疗程5 d。对照组52例给予传统中药及对症治疗。结果治疗组患儿退热时间<5 d 53例(88.3%),退疹时间<6 d 47例(78.3%),卡他症状消失时间<5 d 48例(75.0%),并发症发生15例(18.3%)。对照组退热时间<5 d 28例(53.8%),退疹时间<6 d 14例(26.9%),卡他症状消失时间<5 d 28例(53.8%),并发症发生37例(71.5%),2组比较均有显著性差异(Pa<0.05,0.01)。疗程中未见明显不良反应。结论IFN-α联合多抗甲素治疗小儿麻疹有显著疗效,且安全可靠。

Objective To explore the therapeutic effects and safety of interferon -α（ IFN -α） and polyresistin on measles in children. Methods One hundred and twelve children with measles were selected, measles＇ antibody of all patients were positive, from department of infection of the children＇s hospital affiliated to capital pediatric institute since Jan. 2000 to Jun. 2002 and since Jan. 2007 to Feb. 2008. They were 62 male,50 female, aged 0 - 3 years were 70 cases （ 62.5% ）, 〉 3 - 6 years were 24 cases （21.4%） , 〉 6 - 10 years were 11 cases （9.8%）, 〉 10 - 15 years were 7 cases（6.3% ） ,they were randomly divided into treatment group and contol group. The treatment group with 60 patients were given INF - α and polyresistin, age 〈3 years, given IFN - α 100 000 U per day; and Polyresistin 2.5 mg per time,3 times every day. Age 〉 3 years, given IFN - α 200 000 U per day ; and polyresistin 5 mg per time, 3 times every day, the course of therapy were 5 days. The control group was given traditional Chinese medicine at the same time. Results After therapy, in treatment group, 53 cases （88.3%） of children＇s cooling time were lower than 5 days, 47 cases（78.3% ） of children＇s rash subsided time were lower than 6 days, 48 cases（75% ） of children＇s Catarrhal symptoms disappeared time were lower than 5 days, and the rate of complications＇ occurrence were 15 cases（ 18.3% ）. In control group, 28 cases（53.8% ） of children＇s cooling time were lower than 5 days, 14 cases（26.9% ） of children＇s rash subsided time were lower than 6 days, 28 cases（53.8% ） of children＇s Catarrhal symptoms disappeared time were lower than 5 days, and the rate of complications＇ occurrence were 37 cases（71.5% ）, there were significant differences between both groups（ P 〈 0.05,0.01 ）. And there was no apparent toxicity in treatment group. Conclusions The treatment for measles in children with IFN -α and polyresistin had significant effect, they were safety and reliable to popularize.