活化素及活化素A与脑损伤

Relationships of Activin,Activin A and Brain Injury

活化素是转化生长因子-β超家族成员之一。近年研究发现,活化素及活化素A在各种脑损伤模型中呈异常表达,补充外源性活化素或活化素A对神经元有明显的保护作用。活化素及活化素A可作为一种新的指标预测脑损伤,并为脑损伤的治疗提供新思路。现将活化素及活化素A的研究进展综述如下。

Activin is a growth factor belong to the transforming growth factor - β superfamily. Recently, experimental studies have shown that activin and activin A expressed higher in various brain injury models and aetivin have beneficial roles to neuronal proteetion. The high correlation of aetivin and aetivin A with clinieal and bioehemieal signs of brain injury lead us to suggest that aetivin and aetivin A are new possible indicators to predict and treat brain injury.