番荔枝内酯抗肿瘤作用研究进展

Anti-tumor effects of annonaceous acetogenins

番荔枝内酯（ACG）是一类从多种番荔枝科植物中提取的长碳链脂肪酸内酯，具有广谱抗肿瘤作用。番荔枝内酯来源丰富，具有广阔开发应用前景。动物实验发现，番荔枝内酯毒性较大。目前通过化学修饰或结构改造，提高其抗肿瘤活性、生物利用度并降低毒性，是番荔枝内酯药物的研发方向。

Annonaceous acetogenins（ACG） are a large family of fatty aeid-derivednatural products extracted from annonacea with broad spectrum of anticancer activity. ACG are rich in resources and have broad prospects for development and application. In vivo studies show that ACG have great toxicity, which inhihites their applications and drug development. Chemical modification and structure reformation can improve the antitumor activity and bioavailabilitv of ACC, which will be the direction for ACG anti-tumor drugs research.