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β-谷甾醇抗肿瘤作用研究 被引量：12

Research on beta-sitosteroi＇ s anti-tumor effect
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摘要 β-谷甾醇对肿瘤的发生发展有防治作用，可抑制肿瘤的发生、发展并诱导肿瘤细胞的分化，对肿瘤细胞的抗增殖活性与激活鞘磷脂循环、细胞周期阻滞、刺激肿瘤细胞凋亡、抗氧化活性和免疫功能的调节等相关，β-谷甾醇可作为有效的化学预防药物治疗肿瘤。 Beta-sitosterol have been proposed to offer protection against cancer. Beta-sitosterol could inhibit cancer initiation, progression and induce differentiation. Beta-sitosterol could inhibit tumor growth through stimulating sphingolipid cycle, promoting cell cycle arrest and apoptosis, antioxidant capacity and modulating immune system. Beta-sitosterol could be a potential chemopreventive agent for cancer.
作者 王莉(综述) 归绥琪(审校)
机构地区 复旦大学附属妇产科医院中西医结合科
出处 《国际肿瘤学杂志》 CAS 2009年第9期676-679,共4页 Journal of International Oncology
关键词 Β-谷甾醇 肿瘤 Beta-sitosterol Neoplasmas
分类号 R979.1 [医药卫生—药品] R284.1 [医药卫生—中药学]
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参考文献19

  • 1Awad AB, Chinnam M, Fink CS, et al. Beta-Sitosterol activates Fas signaling in human breast cancer cells. Phytomedicine, 2007, 14 ( 11 ) :747-754.
  • 2Park C, Moon DO, Rhu CH, et al. Beta-sitosterol induces anti-prolif- eration and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol Pharm Bull, 2007, 30(7) :1317-1323.
  • 3Moon DO, Lee KJ, Choi YH, et al. Beta- sitosterol- induced- apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells. Int Immunopharmacol, 2007, 7 (8) :1044-1053.
  • 4Han C, Ding H, Casto B, et al. Inhibition of the growth of premalig- nant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer, 2005, 51 ( 2 ) :207-217.
  • 5Moon DO, Kim MO, Choi YH, et al. beta-Sitosterol induces G2/M arres.t, endoreduplication, and apoptosis through the Bcl-2 and PI3K/ Akt signaling pathways. Cancer Lett, 2008, 264 ( 2 ) : 181 - 191.
  • 6Gao H, Wu L, Kuroyanagi M, et al. Antitumor- promoting constituents from Chaenomeles sinensis Koehne and their activities in JB6 mouse epidermal cells. Chem Phann Bull(Tokyo), 2003, 51 ( 11 ) : 1318- 1321.
  • 7Fahy DM, O' Callaghan YC, O Brien NM. Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture. Food Addit Contain, 2004, 21 (1) :42-51.
  • 8Nakamura Y, Yoshikawa N, Hiroki I, et al. Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk)restores gap junctional intercellular communication in Ha-ras transfected rat liver cells. Nutr Cancer, 2005, 51 (2) :218-225.
  • 9Awad AB, Barta SL, Fink CS, et al. beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Mol Nutr Food Res, 2008, 52(4) :419-426.
  • 10Awad AB, Fink CS, Trautwein EA, et al. beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. J Nutr Biochem, 2005, 16( 11 ) :650-655.

同被引文献208

引证文献12

二级引证文献148

国际肿瘤学杂志
2009年 第9期

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