异丙酚诱导性低血压不同预防方法的比较

Comparison of Different Prevention Methods on Hypotension Induced by Propofol

选择全麻病人45例,分成3组(各15例),诱导方法:对照组(A组)静脉注射异丙酚2.5mg/kg,琥珀酰胆碱1.5mg/kg;麻黄碱组(B组)诱导前给予麻黄碱70μg/kg;扩容组(C组)诱导前扩容液体10ml/kg,分别于诱导前(T_0)、后(T_1)、插管即刻(T_2)、后3分钟(T_3)、后10分钟(T_4)测取血压、心率值.结果血压变化:A组T_1明显下降(P<0.01),T_2上升,T_4下降(P<0.05),B组T_1略升高,T_2明显上升(P<O.01),T_4转为下降,C组T_1、T_2、T_4变化不显著.说明诱导前进行扩容能较好地预防异丙酚性低血压的发生,而麻黄碱能加剧插管时心血管反应,临床应用要慎重.

45 patients on general anesthesia were divided into three groups. The patients in control group(n=15) were managed with propofol(2. 5ml/kg) and succinylcholine(l. 5mg/kg). The patients in ephedrine group(n=15) were managed with ephedrine 70μg/kg before induction. The patients in expansion capacity group(n=15) were managed with infusion of liquid 10ml/kg before induction . Blood pressure and heart rate were measured at pre-inducing, post-inducing, the time of endotra-cheal intubation, 3min of post-intubation and 10 min post-intubation respectively. Control group and ephedrine one have an obvious changes in blood pressure, but expansion capacity group has no significant change . The result showed that the effect of prevention of hypotention by propofol with expanding blood capacity before inducing was better than with ephedrine, which can result in significant cardiovascular reactions under endotracheal intubation.